I’ve been using mouse left handed for a long while after (kind of) breaking my right hand thanks to playing a bit too much rhythm game and too lazy to visit doctor (and that it doesn’t hurt that much).
I initially switched the button using Windows’ built-in mouse button setting but learned that it breaks in various ways ranging from application not honoring the setting to just plain annoyance to having to set the thing at all.
Later I found this hardware-stored profile for certain mice and I’ve been happily using mouse left handed ever since.
There are quite a few things I noticed from switching side.
One main thing I first noticed is how much keyboard shortcuts are located on left side. From the most basic copy/paste, browser tab open/close, closing app, switching app, switching tab, escape key, and some keyboards don’t even have windows key on right side. Those are cause a slight annoyance when using mouse left handed because that means I need to switch position more often than needed. Either that or I just right click and do copy/paste stuff and set my mouse’s 5 additional buttons to do those tasks. I like my mouse.
The other thing is keyboard and mouse positioning is actually more balanced when using keyboard with numpad. The main keys on keyboard are pretty much located on the middle with numpad on right side and mouse on left side. Very convenient.
Oh and I have profile for both sides on my mouse so it’s just clicks away to switch its handedness.
I haven’t used right handed mouse for so long I find it weird now. And my accuracy have dropped as well. Combined with my left hand not being that accurate yet, I probably have overall even less accuracy on my mouse control now.